Christine Chaplin, an 80-year-old black female, was last seen in Freeport, N.Y., at 11 p.m. on Saturday driving a 1992 blue Buick Century with the New York license plate number of N9Y-616.
She may be lost or confused and in need of medical attention, according to the advisory.
Any information should be reported by calling 516-377-2411 or 911.
The alert includes Westchester, Putnam, Rockland and Orange counties as well as Long Island and New York City.
Click here to follow Daily Voice Chappaqua and receive free news updates.